New #blood test for early detection of pre-symptomatic #Parkinson's disease. Based on quantification of specific tRNAs. Still not perfect but an improvement. https://www.nature.com/articles/s43587-025-00851-z
NaturePre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments - Nature AgingMadrer et al. identify a Parkinson’s disease–specific increase in transfer RNA (tRNA) fragments in human blood, cerebrospinal fluid and postmortem brain tissue, demonstrating the ability of blood-based tRNA fragment quantification to distinguish between pre-symptomatic patients and healthy controls.
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