Dave Volek's Pandemic Simulator
Role-play an #epidemiologist trying to manage a pandemic:
Recent searches
Search options
#sars
3 posts2 participants0 posts today
Stammt Sars-CoV-2 aus einem chinesischen Labor? Dieser Frage widmet das Weiße Haus eine neue Webseite. Für US-Präsident Donald Trump scheint die Antwort klar zu sein.#Coronavirus #Sars #DonaldTrump #Medizin
Verdacht eines Laborunfalls: Diskussion über Auslöser der Coronapandemie – Weißes Haus legt sich fest
Verdacht eines Laborunfalls: Diskussion über Auslöser der Coronapandemie – Weißes Haus legt sich fest
DER SPIEGEL · Verdacht eines Laborunfalls: Diskussion über Auslöser der Coronapandemie – Weißes Haus legt sich fest
A doctor from Mount Sinai warns about #SARS-CoV-2 ( #COVID #COVID19 ) establishing persistent infection and causing immune system damage.
"There is no such thing as a COVID infection without consequence"
https://mellowtigger.dreamwidth.org/2025/03/31/the-warning-from-mount-sinai-research.html
Stay safe out there. Keep masking.
mellowtigger.dreamwidth.orgCaptcha Check
"Another point Collins and Wilkinson and agree on, trust was damaged very early in the #pandemic, when officials first told Americans they didn't need to wear masks and then reversed themselves.
Collins explained that, with two earlier coronaviruses, #SARS and #MERS, patients weren't infectious until they got very sick, and so masks weren't needed for people without symptoms."
PBS News · Ex-NIH director and truck driver explore how to bridge divisions deepened by the pandemic
ΘΔ another #NorthCarolina group looking to make public events safer through COVID activism!
queer the air collective is a QTBIPOC mutual aid group based out of "durham, NC" 
besides their work on COVID education on centralized social media...
they opened up a lending library, where they loan an air purifier (currently one so far) for free to community events in the triangle. they have a fundraiser, where they hope to buy more air purifiers to lend out to more events & happenings to make public spaces safer for all!
Queer the Air CollectiveLaunching the Queer the Air CollectiveCleaning the air in the Triangle one air purifier at a time.
Mediterranean diet lowers COVID-19 risk, but its effect on symptoms and severity remains uncertain https://www.diningandcooking.com/1970743/mediterranean-diet-lowers-covid-19-risk-but-its-effect-on-symptoms-and-severity-remains-uncertain/ ##COVID19 ##inflammation #coronavirus #cough #Cytokine #Cytokines #diarrhea #diet #Fever #Fish #food #Frequency #Immunomodulatory #Mediterranean #MediterraneanDiet #Mortality #NasalCongestion #nausea #OliveOil #oxygen #pandemic #SARS #SARSCoV2 #SoreThroat #Throat #VitaminC
Replied in thread
No. No, the world is NOT ready for the next pandemic.
The world isn't ready for the current on-going #SARS-CoV-2 pandemic, or for the delayed impacts on immune failure, rapid aging, long COVID, clotting, and loss of IQ.
#H5N1 will adapt to humans. That is clear.
No we are not ready.
Nor are we ready for #HKU4 #HKU5 #H3N3 or other influenzas, or for the pandemics from immune failure, or Measles, or ....
No, we are not ready.
No, we will not be ready.
Analysis of many #SARS-CoV-2 virus genomes shows that some mutations are more likely in regions where #RNA is unpaired.
https://elifesciences.org/digests/98102/unbalanced-mutations?utm_source=mastodon&utm_medium=social&utm_campaign=organic
eLife Sciences Publications, Ltd · Unbalanced mutationsAnalysis of many SARS-CoV-2 virus genomes shows that some mutations are more likely in regions where RNA is unpaired.
Fünf Jahre nach dem Ausbruch der #Corona-Pandemie sind wir mit dem Netzwerk #MONID (Modellierungsnetz für schwere Infektionskrankheiten) im Falle einer Pandemie künftig besser aufgestellt!
In Berlin treffen sich derzeit mehr als 180 Modelliererinnen und Modellierer. Ihr Ziel: die Kräfte zu bündeln für noch verlässlichere Prognosen.
Weitere Infos: https://monid.net
#Modellierung #Pandemie #SARS-CoV-2 #Infektionsforschung #Epidemiologie #Gesundheitsforschung #Infektionskrankheiten #RKI
"What if the virus behind #COVID-19 did more than just infect cells, but also altered them in a way that could worsen heart disease? A recent study explores this question by investigating how the spike protein of #SARS-CoV-2, the virus causing COVID-19, contributes to heart failure through a process called cellular senescence (when cells lose the ability to replicate themselves). The study uncovers how this viral protein can provoke long-lasting changes in heart cells, even in the absence of active viral infection.
Scientists discovered that the spike protein of SARS-CoV-2, even without the presence of the virus itself, can cause heart cells to become superglued together into larger structures known as syncytia. These globs of cells go into a state of cellular senescence, where the cells stop dividing & begin to secrete inflammatory molecules. This senescent state is characterized by changes that can exacerbate heart failure."
The findings appear in the journal PLOS Pathogens https://doi.org/10.1371/journal.ppat.1012291
journals.plos.orgSARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failureAuthor summary In this paper, we directly linked SARS-2-S-triggered syncytium formation in the absence of infection with the ensuing induction of cellular senescence and its pathophysiological contribution to heart failure. We propose that both SARS-2-S expression and SARS-2-S protein internalization were sufficient to induce senescence in nonsenescent ACE2-expressing cells. This is important because of the persistent existence of SARS-2-S or extracellular vesicles containing SARS-2-S during the post-acute stages of SARS-CoV-2 infection in human subjects. In searching for the underlying molecular mechanisms determining syncytial fate, the formation of functional MAVS aggregates dependent on RIG-I was observed at an early stage during fusion and regulated the anti-death to senescence fate of SARS-2-S syncytia through the TNFα-TNFR2 axis. We also found impaired cardiac metabolism in SARS-2-S syncytia induced by condensed WNK1. However, syncytium formation or cellular senescence observed with the wild-type fusogenic S protein does not occur with the spike proteins produced by currently approved COVID-19 mRNA vaccines. Importantly, SARS-2-S-exacerbated heart failure could be largely rescued by WNK1 inhibitor, anti-syncytial drug or senolytic agent. Together, we suggest that rescuing metabolism dysfunction in senescent SARS-2-S syncytia should be taken into consideration in individuals with post-acute sequelae of COVID-19 (PASC).
I wonder if there were parallels to this pattern of wildlife infections by humans during past epidemics. The world is much more toxic, now, everything's immune system is depleted.
"The #covid_19 virus is widespread amongst wildlife in the United States.
The greatest exposure was found in animals near hiking trails and high-traffic public areas, suggesting that the virus passed from humans to wildlife. Genetic testing of wild animals confirmed both the presence of #SARS-CoV-2 and the existence of unique viral mutations with lineages that closely matched variants circulating in humans at the time, further supporting the idea of human-to-animal transmission.
Researchers identified the virus in deer mice, Virginia opossums, raccoons, groundhogs, Eastern cottontail rabbits, & Eastern red bats.
One possible COVID source is contaminated wastewater, but they think it’s more likely that trash bins & food waste are the main sources."
https://www.forbes.com/sites/grrlscientist/2024/07/29/covid-19-is-widespread-in-common-backyard-wildlife-in-us/?s=04
Forbes · COVID-19 Is Widespread In ‘Common Backyard Wildlife’ In US
Percentage of 18+ #Covid variant lineages sequenced from #SARS-CoV-2 genome found in wastewater. Dec '21- Nov '23. https://biobot.io/data/
️ The totality of all data available strongly supports #masks to reduce #SARS-CoV-2 spread, especially those of high quality.
New report https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2811136
New analysis of flawed Cochrane review https://t.co/qCvbsavBF2 https://substack.com/@erictopol/note/c-42818157?r=ab81u&utm_medium=ios&utm_source=notes-share-action
jamanetwork.comMasks During Pandemics Caused by Respiratory PathogensThis special communication evaluates the evidence on the association of face mask use with the spread of SARS-CoV-2.
Continued thread
"A study from Cornell shows that the #SARS-CoV-2 virus can reprogram genes in Hematopoietic Stem and Progenitor Cells (HSPC) in both humans and mice. SARS-CoV-2 viral infection gene changes can activate #inflammation and affect #immune function for at least a year after COVID infection. Reprogramed monocytes were found to release cytokines and then migrate to the brain and the lung. IL-6 was implicated in this process"
3/n
https://drruth.substack.com/p/covid-news-and-more-82623?utm_medium=email
Dr. Ruth’s NewsletterCOVID news and more 8/26/23
“#OUTDOOR AIR #INFECTIONS ARE POSSIBLE
Study: “Analysis of a super-transmission of #SARS-CoV-2 #omicron variant BA.5.2 in the outdoor night market”
“Aerosols with BA.5.2 strain released by patients could suspend in ambient air up to 1 h 39 min and still be contagious”
Aerosols with viruses can spread over a relatively long distance and stay in ambient air for a long time in a less enclosed space
Important that “aerosol suspension time be considered when identifying and tracing close contact in outbreak investigations”
With today’s #Omicron XBB* lineages and its transmissibility, this will remain a transmission route worthy of our ongoing attention!
https://www.frontiersin.org/articles/10.3389/fpubh.2023.1153303/full?s=09
SOURCE: https://twitter.com/HarrySpoelstra/status/1676189767396884483?t=1G5gZNrRbAfhOBGJQc1sXg&s=19
@eecastro I'm not one to flag wave in geopolitics but I am fascinated by the impact of different political strategies around communication. China tried hard after #sars 1 to set up a system that bypassed chain of command so they'd get early warnings about new viruses but everyone completely ignored it this time around. The tone is set from the top and has consequences for managing outbreaks.