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#neuroscience

117 posts87 participants9 posts today
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Christian Mayer

Our research is now supported by a 2024 Simons Foundation Autism Research Initiative (SFARI) Pilot Award, co-funded by the Nancy Lurie Marks Family Foundation (NLMFF). I am grateful to both SFARI and NLMFF for investing in high-risk, high-reward science to advance understanding of autism spectrum disorders (ASD) and neurodevelopmental disorders.

The project will explore how mutations in chromatin regulators ASH1L and SETBP1 impair their crucial role in guiding the development of GABAergic neurons—key cells maintaining the brain’s balance between excitation and inhibition. Disruptions in this process are strongly linked to ASD, but the molecular pathways remain poorly understood.

By integrating genomic, proteomic, and functional approaches, we aim to reveal how these enzymes regulate gene activity during inhibitory neuron development and how their dysfunction contributes to ASD.

Official announcements:
SFARI: sfari.org/2025/04/08/announcin
NLMFF: nlmfoundation.org/grant/epigen

SFARI · SFARI | Announcing the Recipients of the 2024 Pilot and Pilot Progression AwardsThe Simons Foundation Autism Research Initiative is pleased to announce funding for 23 projects as part of its 2024 Pilot and Pilot Progression awards.
#newsmayerlab#SFARI#NLMFF
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Albert Cardona

Latest from Kathy Nagel's lab:

"Inhibitory control explains locomotor statistics in walking Drosophila", Gattuso et al. 2025
pnas.org/doi/abs/10.1073/pnas.

"we measure and analyze trajectories evoked by attractive odor in walking Drosophila and develop a biologically plausible computational model of trajectory generation and modulation by sensory input. Our model provides a link between neural architectures and locomotor behavior and highlights the potential role of inhibition in shaping the curvature and speed of trajectories. Inspired by this model, we experimentally identify single neurons and populations that modulate either curvature or speed in the manner predicted by our model."

#neuroscience#Drosophila#locomotion
Public
Dennis A

#Consciousness #Neuroscience #thalamus
"A team of scientists has identified areas of the brain that are activated when a person becomes aware of themself and their thoughts."

Scientists Think They’ve Found the Region of the Brain That Regulates Conscious Perception

"A new experiment suggests that the thalamus plays a key role in humans becoming consciously aware of stimuli their brain receives."
wired.com/story/scientists-thi

WIRED · Scientists Think They’ve Found the Region of the Brain That Regulates Conscious PerceptionBy Jorge Garay
Public
Embedded Podcast

Imagine controlling machines with only your thoughts! Brain-Computer Interfaces (BCIs) are turning stuff of sci-fi into reality, and Mouser Electronics is leading the way.

Mouser has great content about this tech on their Empowering Innovation Together platform.
Check out mouser.com/empowering-innovation to see how their tech is shaping the future.

Thank you to Mouser Electronics for sponsoring Embedded.

#BCI#engineering#neuroscience
Public
Joseph Meyer

I finished reading Consciousness Explained by Daniel Dennett last night. I liked the author’s interdisciplinary approach to his theory of consciousness. He accomplished his aim of causing me to think differently, and I expect to continue thinking about what I read when I’m less sleepy. One trivial way the book influenced me is by changing my opinion from “hating AI” to “hating how AI is used today.” I think AI can be more useful in research for understanding consciousness, than as a tool for profit. #Consciousness #Philosophy #Psychology #Neuroscience #AI #Dennett #DanielDennett
#Books #ComputerScience #Science

Public
lmf

Nonequilibrium physics of brain dynamics
arxiv.org/abs/2504.12188

"Information processing in the brain is coordinated by the dynamic activity of neurons and neural populations at a range of spatiotemporal scales. These dynamics, captured in the form of electrophysiological recordings and neuroimaging, show evidence of time-irreversibility and broken detailed balance suggesting that the brain operates in a nonequilibrium stationary state. Furthermore, the level of nonequilibrium, measured by entropy production or irreversibility appears to be a crucial signature of cognitive complexity and consciousness."

arXiv logo
arXiv.orgNonequilibrium physics of brain dynamicsInformation processing in the brain is coordinated by the dynamic activity of neurons and neural populations at a range of spatiotemporal scales. These dynamics, captured in the form of electrophysiological recordings and neuroimaging, show evidence of time-irreversibility and broken detailed balance suggesting that the brain operates in a nonequilibrium stationary state. Furthermore, the level of nonequilibrium, measured by entropy production or irreversibility appears to be a crucial signature of cognitive complexity and consciousness. The subsequent study of neural dynamics from the perspective of nonequilibrium statistical physics is an emergent field that challenges the assumptions of symmetry and maximum-entropy that are common in traditional models. In this review, we discuss the plethora of exciting results emerging at the interface of nonequilibrium dynamics and neuroscience. We begin with an introduction to the mathematical paradigms necessary to understand nonequilibrium dynamics in both continuous and discrete state-spaces. Next, we review both model-free and model-based approaches to analysing nonequilibrium dynamics in both continuous-state recordings and neural spike-trains, as well as the results of such analyses. We briefly consider the topic of nonequilibrium computation in neural systems, before concluding with a discussion and outlook on the field.
#neuroscience#dynamical_systems#consciousness
Public
EPFL

👂 A team from the Laboratory for Soft Bioelectronic Interfaces has developed a flexible auditory brainstem implant (ABI) that closely conforms to the curved surface of the brainstem. The technology has successfully demonstrated high-resolution “prosthetic hearing” in macaques.

👉 go.epfl.ch/7df649

go.epfl.ch · Soft brainstem implant delivers high-resolution hearingEPFL researchers have developed a flexible auditory brainstem implant (ABI) that closely conforms to the curved surface of the brainstem. The technology has been successfully demonstrated high-resolution “prosthetic hearing” in macaques.
#BrainstemImplant#ProstheticHearing#Neuroscience
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